4. kuşak Flurokinolonlar DNA TopoizomerazII&IV inhibisyonu yaparlar. 4. kuşak kinolonlar: Moksifl oksasin, gemifl oksasin, gatifl oksasin gibi ilaçlardır
|
Topoisomerase |
Subfamily Type |
|
Topoisomerase I (E. coli) |
Type IA |
|
Topoisomerase III (E. coli) |
|
|
Topoisomerase IIIα (H. sapiens) |
|
|
Topoisomerase IIIβ (H. sapiens) |
|
|
Reverse DNA Gyrase (E. coli) |
|
|
Reverse DNA Gyrase (Archaea) |
|
|
(H. sapiens) |
Type IB |
|
Topoisomerase V (Archaea) |
Type IC |
|
Topoisomerase II / DNA Gyrase (E. coli) |
Type IIA |
|
(E. coli) |
|
|
Topoisomerase IIα (H. sapiens) |
|
|
Topoisomerase IIβ (H. sapiens) |
|
|
Topoisomerase VI (Archaea) |
Type IIB |